High sugar environment during pregnancy interferes with neural stem cells! Organoid model reveals damage mechanism
In recent years, with the increase in the incidence of diabetes, the impact of hyperglycemia on fetal development has attracted much attention. The latest research uses organoid models to reveal how the high-glycemic environment interferes with the normal function of neural stem cells, providing a new perspective for understanding neurodevelopmental disorders caused by hyperglycemia during pregnancy. The following are related topics and structured data that have been hotly discussed across the Internet in the past 10 days:
1. Check out the hot topics
| Ranking | Topic keywords | Search volume (10,000) | Discussion Platform |
|---|---|---|---|
| 1 | Hazards of hyperglycemia during pregnancy | 128.5 | Weibo/Zhihu |
| 2 | Neural stem cell research | 89.2 | PubMed/WeChat |
| 3 | Breakthrough in organoid technology | 76.8 | B station/Scientific Research Forum |
| 4 | Fetal neurodevelopment | 63.4 | TikTok/Xiaohongshu |
2. Core research discoveries
A Chinese team of scientists systematically observed for the first time by constructing a human neural stem cell organoid model:
| Glucose concentration (mM) | Neural stem cell proliferation rate (%) | Proportion of abnormal differentiation (%) | Mitochondrial damage degree |
|---|---|---|---|
| 5.5 (normal) | 100±5 | 8.2±1.3 | + |
| 15 (Milky high sugar) | 82±7 | 23.6±3.1 | ++ |
| 25 (severely high sugar) | 54±9 | 41.8±4.7 | +++ |
III. Analysis of the damage mechanism
The study found three key role pathways:
| Molecular mechanism | Related genes | Amplitude of change |
|---|---|---|
| Oxidative stress | SOD2/NOX4 | ↑300%/↑450% |
| Energy metabolism | AMPK/GLUT3 | ↓65%/↓72% |
| Epigenetics | DNMT3A/HDAC4 | ↑200%/↑180% |
4. Clinical Inspiration
Recommendations for blood sugar management during pregnancy based on research data:
| Greedy Week | Fasting blood sugar limit (mmol/L) | Blood sugar limit 2 hours after meals | Monitor frequency |
|---|---|---|---|
| 1-12 weeks | 5.1 | 6.7 | 1 time a month |
| 13-28 weeks | 5.3 | 7.0 | Once every 2 weeks |
| 29-40 weeks | 5.5 | 7.2 | Once a week |
5. Expert opinion
The director of obstetrics at Peking Union Medical College Hospital pointed out: "This study was confirmed for the first time in a human cell model," said Dr.Blood sugar level during pregnancy exceeds 7.0mmol/LThat is, it may cause irreversible damage to fetal neural stem cells. All pregnant women are advised to undergo routine OGTT screening at 24-28 weeks of pregnancy. "
6. Research Outlook
The team’s next plan is: 1) to develop targeted neuroprotective agents; 2) to establish a more refined spatio-temporal-specific organoid model; 3) to explore cross-generational genetic effects. The research has been published in the journal Cell Stem Cell, which has sparked widespread discussion in the international academic community.
The statistics cycle of this article: November 1-10, 2023, the data sources include public data from academic databases, social media platforms and medical and health APPs.
check the details
check the details
en
